Human cardiac stem cell differentiation is regulated by a mircrine mechanism.

Letter by Sluijter et al regarding article, "Human cardiac stem cell differentiation is regulated by a mircrine mechanism".

The mircrine mechanism controlling cardiac stem cell fate

The recent identification of c-kit-positive cardiac stem cells revealed the great growth reserve of the heart, in which connection among cells might be essential in regulating their fate. Especially, the mircrine mechanism, translocation of microRNAs (miRs) from a cell to another via gap junctions, appeared to be important in controlling the differentiation of cardiac stem cells. The modificati...

Heart Failure Human Cardiac Stem Cell Differentiation Is Regulated by a Mircrine Mechanism

Background—Cardiac stem cells (CSCs) delivered to the infarcted heart generate a large number of small fetal-neonatal cardiomyocytes that fail to acquire the differentiated phenotype. However, the interaction of CSCs with postmitotic myocytes results in the formation of cells with adult characteristics. Methods and Results—On the basis of results of in vitro and in vivo assays, we report that t...

Evaluation of In Vitro Differentiation of Cardiomyocyte-like cells Derived from Human Bone Marrow Mesenchymal Stem Cells

Purpose: To investigate the in vitro differentiation process of cardiomyocyte-like cells derived from human bone marrow mesenchymal stem cells under the influence of 5-azacytidine (5-aza). Materials and Methods: After purification, human bone marrow mesenchymal stem cells were exposed to 5-aza at a concentration of 5 μmol for 5 weeks to induce cardiomyocyte differentiation. To induce differenti...

Evaluation of the Effect of Platelet-Rich Plasma on Proliferation and Differentiation of Human Dental Pulp Stem Cells with or without Ga-Al-As Laser

Background Recently, the clinical use of low power lasers has increased, and it is said that wound healing is accelerated by their irradiation. The aim of this study was evaluation of the effect of platelet-rich plasma on proliferation and differentiation of human dental pulp stem cells with or without Ga-Al-As laser. Methods: In this experimental study, human lower third molar dental pulp c...